synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4h-chromenes
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abstract
a series of 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4 h -chromenes was synthesized by condensation of 3-(dimethylamino)phenol, an aromatic aldehyde and malonitrile in ethanol containing piperidine. the assignments of the structure of all synthesized compounds were based on spectral data (ir, mass and 1 h nmr). the cytotoxic activities of the synthesized compounds against six human tumor cell lines were determined by mtt assay. several compounds showed significant cytotoxic activity.
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Journal title:
research in pharmaceutical sciencesجلد ۵، شماره ۱، صفحات ۹-۰
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